Hotels with Suites in Picayune available. Book today!

Can't find a Florida Rental Vacations or vacation rental in Picayune, US? We have many Hotel Suites in Picayune, from budget to luxury, to suit your needs as well.

Our site boasts of more than 8 hotels listings near Picayune. Whether you are going on a business trip, leisure vacation with a group, or traveling with your family or friends for summer or winter break, there’s always something perfect for you.

If you want to experience a great trip, we have thousands of hotels, resorts, or motels with updated prices for 2026. Florida Rental Vacations hotels in top destinations are available for last-minute booking deals, including top brand hotel chains such as Radisson Hotel, OYO, Marriott, Hyatt, Hilton, MGM Resorts, & more.