538+ Vacation Rentals Near Mayo Clinic Florida |
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Floridarentalvacations - Vacation Rentals in Mayo Clinic Florida

Property Image From US $867
         

10.0 (110 Reviews)
House
Serene Escape, Heated Pool, Spa, Outdoor Dining & Putting Green
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $387
         

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New
House
Jacksonville Home, Near Beach and Mayo Clinic!
  • Parking
  • Pet Friendly
  • Pool

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Property Image From US $179
         

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9.4 (440 Reviews)
Hotel
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
  • Air Conditioner
  • Parking
  • Pool

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Property Image From US $689
         

10.0 (106 Reviews)
House
Family-Friendly Luxe Home with Heated Pool & Games
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $177
         

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10.0 (7 Reviews)
House
Walk to Beach - Fully Renovated Modern Jax Beach Retreat
  • Air Conditioner
  • Parking
  • View

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Property Image From US $139
         

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9.4 (22 Reviews)
Hotel
Hilton Jacksonville At Mayo Clinic
  • Air Conditioner
  • Parking
  • Pool

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Property Image From US $123
         

10.0 (70 Reviews)
Cottage
Private Beachy Guest Cottage!
  • Air Conditioner
  • Parking
  • TV

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Property Image From US $539
         

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New
House
Heated Pool Pet friendly Home
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $126
         

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9.2 (1003 Reviews)
Hotel
Holiday Inn Express Jacksonville Beach by IHG
  • Air Conditioner
  • Parking
  • Pool

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Property Image From US $435
         

10.0 (68 Reviews)
House
Stunning Back Patio & Heated Pool
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $393
         

10.0 (54 Reviews)
House
Isla's Beach Oasis: Family Beach Oasis with Heated Pool
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $511
         

10.0 (48 Reviews)
House
Family Oasis | Pickleball + Heated Pool & Spa
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $547
         

10.0 (44 Reviews)
House
5 BR luxury Beach house 5 min walk to beach
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $475
         

10.0 (42 Reviews)
House
WOW 4 blocks to beach w/Unique POOL! 3min walk to local coffee/shops/playground
  • Air Conditioner
  • Parking
  • Pool

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Property Image From US $495
         

10.0 (40 Reviews)
House
Spacious Coastal Home with Heated Pool
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $453
         

10.0 (31 Reviews)
House
Classic Beach Bungalow with Casita and Heated Pool
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $308
         

10.0 (31 Reviews)
House
Northeast Florida Retreat
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $1,120
         

10.0 (30 Reviews)
House
Jax Beach Escape | Heated Pool + Key West Charm
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $211
         

10.0 (30 Reviews)
House
Cozy & Comfy 3 bedroom residential home
  • Air Conditioner
  • Parking
  • TV

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Property Image From US $404
         

10.0 (28 Reviews)
House
Tranquility by Mayo w/Heated Pool Mins to Beach
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $366
         

10.0 (27 Reviews)
House
Heated Pool & Game Room! The Sunshine Cottage
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $186
         

10.0 (27 Reviews)
Apartment
Suite Nest @ The Beach 🏝️
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $936
         

10.0 (25 Reviews)
House
Coco Villa: Luxury stay, Heated Pool, 3 Blocks to Beach
  • Air Conditioner
  • Parking
  • Pet Friendly

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Property Image From US $717
         

10.0 (24 Reviews)
House
Chic Beach Stay Heated Pool Epic Game Room
  • Air Conditioner
  • Parking
  • Pet Friendly

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★ Pro Tip: Floridarentalvacations makes it easy to compare the best listings on Floridarentalvacations homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Floridarentalvacations homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Mayo Clinic Florida.

Weather in Mayo Clinic Florida

View the weather forecast for Mayo Clinic Florida before booking your Mayo Clinic Florida Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Top Attractions Around Mayo Clinic Florida, FL

Floridarentalvacations offers a large selection of top attractions around Mayo Clinic Florida. Research things to do on your vacation before you visit Mayo Clinic Florida.


St. Johns Town Center TPC Sawgrass Mayport Naval Station University of North Florida Jacksonville University Memorial Hospital Jacksonville Jacksonville Beach Pier Adventure Landing The Avenues Oceanfront Park Kathryn Abbey Hanna Park San Jose Country Club Ponte Vedra Concert Hall Beaches Town Center Kingsley Plantation Saint Vincent's Medical Center Southside Regency Square TPC at Sawgrass Stadium Course Jacksonville Beach Golf Club Morocco Shrine Center